The requirement for membrane sialic acid in the stimulation of superoxide production during phagocytosis by human polymorphonuclear leukocytes
نویسندگان
چکیده
The effect of desialylation on phagocytosis of latex particles and oxidative metabolism of human polymorphonuclear leukocytes was studied. Removal of 20% total leukocyte sialic acid by bacterial neuraminidase had no effect on phagocytosis of latex particles and phagocytosis-associated activation of hexose monophosphate shunt in human polymorphonuclear leukocytes. In contrast, desialylation prevented the stimulation of superoxide production either by phagocytosis or by concanavalin A. It is concluded that membrane sialic acid is essential for the stimulation of superoxide production by human polymorphonuclear leukocytes.
منابع مشابه
Tsan Any Patricia
Phagocytosis of particles by polymorphonuclear leukocytes (PMN) 1 is accompanied by a burst of oxidative metabolic changes. These include increased oxygen consumption (1), hexose monophosphate shunt (HMS) activity (1), and hydrogen peroxide (H202) (2) and superoxide (02-) (3) production. Despite intensive investigation the mechanism by which this oxidative metabolism is stimulated during phagoc...
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ورودعنوان ژورنال:
- The Journal of Experimental Medicine
دوره 143 شماره
صفحات -
تاریخ انتشار 1976